At age 13, he formed a musical group by the name of the Shephards, which included the daughter of Freddie McGregor and son of Third World's Cat Core. The group opened the 1992 Reggae Sunsplash festival. The band fell apart in the early 1990s and Damian started his solo career.
With the backing of his father’s label, Tuff Gong, he released his 1996 debut album Mr. Marley which surprised many who were unaccustomed to hearing a Marley deejaying rather than singing. Marley released his second studio album Halfway Tree. The name "Halfway Tree" comes from his mother, Cindy Breakspeare, being from the rich part of town, and his father, Bob Marley, coming from the poor part of town, thus him being "a tree halfway in between the 'rich' world and 'poor' world."
Additionally, Halfway Tree is a well-known landmark that marks the cultural center of Half-Way-Tree, the clock tower that stands where the historical eponymous cotton tree once stood is featured prominently behind Marley on the cover of the album. The album was released on September 11, 2001 and received the 2002 Grammy Award for Best Reggae Album. It was co-produced by Damian Marley and his brother Stephen Marley.
At the 2009 Grammy Awards, he won Best Reggae Album and Best Urban/Alternative Performance for Welcome to Jamrock. He is the only Jamaican reggae artist in history to win two Grammy Awards on the same night. He is also the only reggae artist to win in the Best Urban/Alternative Performance category at the Grammy Awards. At the 2009 Grammy Awards news of a collaborative album between Marley and Nas was announced, when Nas told MTV reporters "Right now, I'll tell you first, I'm working on an album with Damian Marley. We tryin' to build some schools in Africa with this one, and trying to build empowerment. We're tryin' to show love and stuff with this album. So, the record's … all about really the 'hood and Africa also as well.
SUPERHEAVY - The existence of SuperHeavy was secret until May 2011. Mick Jagger, English musician and the lead vocalist of rock band The Rolling Stones, announced its formation on 20 May 2011. SuperHeavy was Dave Stewart's idea. Inspired by the sounds washing into his home in St Ann's Bay, Jamaica, Stewart urged Jagger to fuse their sound with that of Indian orchestras. Stewart and Jagger had mutual liking for Indian orchestrations; thus, A. R. Rahman was added to the supergroup. The name of the band is said to be inspired by Muhammad Ali. The group began recording their self-titled debut album in early 2009 at a studio in Los Angeles. They recorded about 35 hours of music, with some songs originally lasting "an hour and 10 minutes" before they were whittled down The album was previewed at Jim Henson Studios, Los Angeles, on 30 June 2011. The band played eight of the recorded songs at the event.
"Miracle Worker" was released on iTunes as the album's lead single on 7 July 2011. It is a reggae song performed by Marley, Stone and Jagger. The single entered at number 195 on the UK Singles Chart. The music video was released on YouTube on 12 August 2011. Directed by Stewart and filmed at Paramount Studios in Los Angeles, the video features all five members of the band. "Satyameva Jayathe" (the national motto of India, which literally translates as "Truth Alone Triumphs") was released as the second single from the album on 9 August 2011, a week before India's Independence Day on 15 August. Composed by Rahman to have an Indian feel, Jagger sings in Sanskrit on the song, which also features Stewart, Stone and Marley. The song premiered exclusively on Radio Mirchi 98.3 FM on 9 August across twenty-two Indian cities, and Tata DoCoMo is set to simultaneously promote the song and the album on mass media. "Beautiful People" reached number sixty-four on the Dutch Single Top 100 chart.
Damian also worked with electronic artist Skrillex on a song called "Make It Bun Dem" in 2012. This song also appears in the 2012 game Far Cry.